SMG7

Across TCGA pan-cancer cohorts, SMG7 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SMG7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMG7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SMG7 is over-expressed in tumor.

HNSC, LSCC, and LUAD are the cancer types where SMG7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMG7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.386	<.001	12	view →
LSCC	Male	II,III,IV	+0.458	<.001	9	view →
LUAD	Male	All	+0.411	<.001	9	view →
CCRCC	Male	II,III,IV	+0.203	<.001	9	view →
COAD	Male	All	+0.284	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SMG7–HNSC

Open the HNSC breakdown →