SMG7

Across TCGA patient cohorts, SMG7 mutation is significantly associated with the RNA expression of many other genes, with 2,936 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG7-associated genes across cancer lineages are RNU6-705P, RAD51C, and SC5D. Each is linked with SMG7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMG7-to-partner and partner-to-SMG7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-705P grouped by SMG7-low versus SMG7-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG7→partner) and Y-score (partner→SMG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-705P →	+0.769	+3.091	<.001	.007	3	3
UCEC	RAD51C →	+0.324	+1.595	.005	.003	3	3
UCEC	SC5D →	+0.407	+1.950	.008	.002	3	3
UCEC	CEBPA-DT →	-0.521	-2.767	.004	.003	3	3
LIHC	MIR6864 →	+0.653	+4.378	<.001	.006	3	2
PRAD	POLR2DP2 →	+0.116	+5.420	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,936 associations by consensus.

RNU6-705P by SMG7 expression — CESC

Explore this box plot interactively →