SMG7

Across TCGA cell cohorts, SMG7 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,004 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMG7-associated GO terms across cancer lineages are Regulatory ncRNA-mediated gene silencing, Heterochromatin formation, and Epigenetic regulation of gene expression. Each is linked with SMG7 in more than 17 cancer types. Because this analysis shows association rather than direction, both SMG7-to-partner and partner-to-SMG7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulatory ncRNA-mediated gene silencing grouped by SMG7-low versus SMG7-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG7→partner) and Y-score (partner→SMG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulatory ncRNA-mediated gene silencing →	+0.103	+1.152	<.001	<.001	3	18
BONE	Heterochromatin formation →	+0.081	+0.900	.002	.002	3	18
BONE	Epigenetic regulation of gene expression →	+0.093	+0.936	<.001	.001	3	18
BONE	RNA 3'-end processing →	+0.095	+0.921	.002	.002	3	17
BONE	Negative regulation of gene expression, epigenetic →	+0.088	+0.965	.001	.001	3	17
BONE	mRNA transport →	+0.143	+0.927	<.001	.002	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,004 associations by consensus.

Regulatory ncRNA-mediated gene silencing by SMG7 expression — BONE

Explore this box plot interactively →