SMG7

Across TCGA cell cohorts, SMG7 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible SMG7-associated genes across cancer lineages are MMD2, ASIC2, and NPHS2. Each is linked with SMG7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMG7-to-partner and partner-to-SMG7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMD2 grouped by SMG7-low versus SMG7-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG7→partner) and Y-score (partner→SMG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	2
URINARY_TRACT	ASIC2 →	+0.780	+3.523	<.001	.009	3	1
URINARY_TRACT	NPHS2 →	+0.125	+3.459	.003	.002	3	1
URINARY_TRACT	TINAG →	+2.450	+3.584	<.001	.008	3	1
URINARY_TRACT	CELA2A →	+0.076	+3.459	<.001	.002	3	1
URINARY_TRACT	SAXO1 →	+0.072	+3.584	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MMD2 by SMG7 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →