SMG6

Across TCGA pan-cancer cohorts, SMG6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMG6 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SMG6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SMG6 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where SMG6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.971	0.666	.002	22	view →
CCRCC	DFS	Tertile	IV	0.961	0.183	.017	21	view →
HNSC	OS	Quartile	II,III,IV	0.776	0.541	.020	6	view →
PDAC	DFS	Tertile	IV	0.203	0.741	.024	3	view →
GBM	DFS	Quartile	All	0.457	0.273	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMG6–LSCC (OS)

Open the LSCC breakdown →