SMG6

Across TCGA patient cohorts, SMG6 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG6-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and FASN. Each is linked with SMG6 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMG6-to-partner and partner-to-SMG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SMG6-low versus SMG6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG6→partner) and Y-score (partner→SMG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.690	+3.467	<.001	.002	3	3
COAD	Caspase-7-cleavedD198 →	+1.437	+3.467	<.001	.002	3	3
COAD	FASN →	+0.495	+2.330	.004	.020	3	2
COAD	GAPDH →	+0.802	+2.330	<.001	.020	3	2
COAD	INPP4B →	-0.505	-3.321	.002	.009	3	2
UCEC	PCNA →	+0.227	+2.485	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

ASNS by SMG6 expression — COAD

Explore this box plot interactively →