SMG6

Across TCGA cell cohorts, SMG6 mutation is significantly associated with the RNA expression of many other genes, with 967 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMG6-associated genes across cancer lineages are FBXW10, ADAM7, and F11. Each is linked with SMG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMG6-to-partner and partner-to-SMG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by SMG6-low versus SMG6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG6→partner) and Y-score (partner→SMG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.229	+3.906	<.001	<.001	3	2
BLOOD_Leukemia	ADAM7 →	+0.014	+4.507	.006	.001	3	2
BLOOD_Leukemia	F11 →	+0.107	+3.855	<.001	.007	3	2
LARGE_INTESTINE	FAM205A →	+0.018	+3.614	<.001	<.001	3	2
OESOPHAGUS	CCDC141 →	+0.200	+3.977	.003	.006	3	1
BREAST	RETNLB →	+0.041	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 967 associations by consensus.

FBXW10 by SMG6 expression — LARGE_INTESTINE

Explore this box plot interactively →