Across TCGA patient cohorts, SMG5 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,852 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMG5-associated proteins across cancer lineages are HDGF, RPRD2, and ADAR. Each is linked with SMG5 in more than 6 cancer types. Because this analysis shows association rather than direction, both SMG5-to-partner and partner-to-SMG5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG5→partner) and Y-score (partner→SMG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HDGF →	+0.329	+0.242	.004	.004	3	7
GBM	RPRD2 →	+0.272	+0.290	.002	<.001	3	6
BRCA	ADAR →	+0.264	+0.472	.001	<.001	3	6
BRCA	C1orf35 →	+0.384	+0.384	<.001	.003	3	6
LSCC	DHX9 →	+0.234	+0.484	<.001	<.001	3	6
LSCC	GATAD2B →	+0.356	+0.611	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,852 associations by consensus.

Exploration

SMG5 survival (RNA) · tumor vs normal (RNA) · all SMG5 data types