Across TCGA patient cohorts, SMG5 protein abundance is significantly associated with the RNA expression of many other genes, with 12,225 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SMG5-associated genes across cancer lineages are DARS2, AURKA, and MRGBP. Each is linked with SMG5 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMG5-to-partner and partner-to-SMG5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG5→partner) and Y-score (partner→SMG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DARS2 →	+0.645	+0.223	<.001	<.001	3	5
BRCA	AURKA →	+0.875	+0.192	<.001	<.001	3	5
BRCA	MRGBP →	+0.655	+0.291	<.001	<.001	3	4
GBM	SH3D19 →	-1.046	-0.165	<.001	.001	3	4
BRCA	NEK2 →	+0.947	+0.194	<.001	<.001	3	4
BRCA	DLGAP5 →	+0.928	+0.234	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,225 associations by consensus.

Exploration

SMG5 survival (RNA) · tumor vs normal (RNA) · all SMG5 data types