Across TCGA patient cohorts, SMG5 mutation is significantly associated with the RNA expression of many other genes, with 2,195 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG5-associated genes across cancer lineages are FCGR3A, CCL4, and RASSF1-AS1. Each is linked with SMG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMG5-to-partner and partner-to-SMG5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG5→partner) and Y-score (partner→SMG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FCGR3A →	+1.275	+2.249	.001	.006	3	3
COAD	CCL4 →	+1.144	+2.906	<.001	.001	3	3
UCEC	RASSF1-AS1 →	+0.575	+2.780	<.001	<.001	3	3
UCEC	PACRG →	-1.029	-1.736	<.001	<.001	3	3
UCEC	CD207 →	-0.690	-1.536	<.001	.002	3	3
UCEC	CXCL9 →	+1.757	+2.192	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,195 associations by consensus.

Exploration

SMG5 survival (RNA) · tumor vs normal (RNA) · all SMG5 data types