Across TCGA patient cohorts, SMG5 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG5-associated genes across cancer lineages are PCNA, TFRC, and ATM. Each is linked with SMG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMG5-to-partner and partner-to-SMG5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG5→partner) and Y-score (partner→SMG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.245	+2.123	.012	.010	3	3
UCEC	TFRC →	+0.451	+1.700	.008	.040	3	3
COAD	ATM →	-0.548	-2.321	<.001	.032	3	3
LUSC	HER3 →	+0.421	+2.816	.007	.036	3	2
UCEC	INPP4B →	-0.253	-2.087	.016	.004	3	2
UCEC	ACVRL1 →	-0.102	-1.687	.020	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

SMG5 survival (RNA) · tumor vs normal (RNA) · all SMG5 data types