SMG1P7

Across TCGA patient cohorts, SMG1P7 mutation is significantly associated with the RNA expression of many other genes, with 786 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG1P7-associated genes across cancer lineages are MIR8053, RNA5-8SP7, and RNA5SP517. Each is linked with SMG1P7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMG1P7-to-partner and partner-to-SMG1P7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by SMG1P7-low versus SMG1P7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG1P7→partner) and Y-score (partner→SMG1P7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR8053 →	+0.320	+3.997	<.001	.001	3	2
BLCA	RNA5-8SP7 →	+0.207	+7.640	<.001	.009	3	1
BLCA	RNA5SP517 →	+0.263	+7.640	<.001	.009	3	1
UCEC	CNIH1 →	+0.603	+3.354	.004	.005	3	1
UCEC	VTI1B →	+0.474	+3.459	.005	.005	3	1
UCEC	INTS6 →	+0.479	+3.491	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 786 associations by consensus.

MIR8053 by SMG1P7 expression — UCEC

Explore this box plot interactively →