SMG1P7

Across TCGA patient cohorts, SMG1P7 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG1P7-associated genes across cancer lineages are Gab2, Cyclin-E2, and STAT3_pY705. Each is linked with SMG1P7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMG1P7-to-partner and partner-to-SMG1P7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by SMG1P7-low versus SMG1P7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG1P7→partner) and Y-score (partner→SMG1P7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.510	+3.000	.013	.037	3	1
UCEC	Cyclin-E2 →	+0.245	+2.817	.011	.036	2	1
UCEC	STAT3_pY705 →	-0.533	-3.000	<.001	.037	1	1
UCEC	Tuberin →	+0.472	+3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Gab2 by SMG1P7 expression — UCEC

Explore this box plot interactively →