SMG1P3

Across TCGA patient cohorts, SMG1P3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG1P3-associated genes across cancer lineages are VHL, p62 Lck ligand, and Src_pY416. Each is linked with SMG1P3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMG1P3-to-partner and partner-to-SMG1P3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by SMG1P3-low versus SMG1P3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG1P3→partner) and Y-score (partner→SMG1P3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.841	-3.000	.032	.037	3	1
UCEC	p62 Lck ligand →	+0.548	+2.817	.003	.036	2	1
UCEC	Src_pY416 →	-0.307	-2.986	.027	.037	2	1
UCEC	Caspase-8 →	-0.336	-3.000	.020	.037	2	1
UCEC	IGFBP2 →	-0.786	-3.000	.036	.037	1	1
UCEC	MEK1 →	+0.598	+3.000	.004	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

VHL by SMG1P3 expression — UCEC

Explore this box plot interactively →