SMG1

Across TCGA patient cohorts, SMG1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,988 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMG1-associated proteins across cancer lineages are USP7, THUMPD1, and DDX41. Each is linked with SMG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMG1-to-partner and partner-to-SMG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMG1 versus USP7 in LSCC, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG1→partner) and Y-score (partner→SMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP7 →	+0.255	+0.516	<.001	<.001	3	5
LUAD	THUMPD1 →	+0.302	+0.368	<.001	<.001	3	5
PDAC	DDX41 →	+0.201	+0.248	<.001	.001	3	5
LSCC	HIRIP3 →	+0.485	+0.497	<.001	<.001	3	5
LSCC	NFATC2IP →	+0.387	+0.553	<.001	<.001	3	5
LSCC	USP10 →	+0.238	+0.375	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,988 associations by consensus.

SMG1 vs USP7 — LSCC

Explore this scatter interactively →