SMG1

Across TCGA patient cohorts, SMG1 mutation is significantly associated with the RNA expression of many other genes, with 5,767 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG1-associated genes across cancer lineages are ENO1, NCAPG, and CHAF1B. Each is linked with SMG1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMG1-to-partner and partner-to-SMG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENO1 grouped by SMG1-low versus SMG1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG1→partner) and Y-score (partner→SMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ENO1 →	+0.582	+3.347	.003	.004	3	6
BRCA	NCAPG →	+0.915	+2.711	.001	.003	3	5
COAD	CHAF1B →	+0.621	+2.611	<.001	<.001	3	5
BRCA	CHAF1A →	+0.545	+2.705	.002	.003	3	5
BRCA	WDR62 →	+0.759	+3.366	<.001	.005	3	5
SKCM	GMNN →	+0.561	+2.106	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,767 associations by consensus.

ENO1 by SMG1 expression — STAD

Explore this box plot interactively →