SMG1

Across TCGA patient cohorts, SMG1 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SMG1-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with SMG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SMG1-to-partner and partner-to-SMG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SMG1-low versus SMG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG1→partner) and Y-score (partner→SMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.523	+2.000	<.001	.027	3	5
COAD	Caspase-7-cleavedD198 →	+1.107	+2.593	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.386	+1.584	.003	.007	3	4
STAD	MYH11 →	-1.409	-3.169	.019	.018	2	4
STAD	4E-BP1 →	+0.306	+2.700	.011	.005	3	3
STAD	Cyclin-E2 →	+0.152	+3.190	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

ASNS by SMG1 expression — COAD

Explore this box plot interactively →