SMG1

Across TCGA cell cohorts, SMG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,360 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMG1-associated GO terms across cancer lineages are RNA export from nucleus, Phosphatidylinositol biosynthetic process, and Endosomal transport. Each is linked with SMG1 in more than 17 cancer types. Because this analysis shows association rather than direction, both SMG1-to-partner and partner-to-SMG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA export from nucleus grouped by SMG1-low versus SMG1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG1→partner) and Y-score (partner→SMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA export from nucleus →	+0.105	+0.717	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.072	+1.253	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.079	+1.349	<.001	<.001	3	17
STOMACH	Cytosolic transport →	+0.082	+1.118	.001	.001	3	17
PANCREAS	Peptidyl-serine phosphorylation →	+0.074	+0.936	<.001	.001	3	17
BONE	Nucleic acid transport →	+0.096	+0.696	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,360 associations by consensus.

RNA export from nucleus by SMG1 expression — BONE

Explore this box plot interactively →