SMG1

Across TCGA cell cohorts, SMG1 mutation is significantly associated with the RNA expression of many other genes, with 2,267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMG1-associated genes across cancer lineages are FANCE, NPIPA8, and DIMT1. Each is linked with SMG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMG1-to-partner and partner-to-SMG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCE grouped by SMG1-low versus SMG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG1→partner) and Y-score (partner→SMG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FANCE →	+0.421	+2.584	.001	.002	3	3
LARGE_INTESTINE	NPIPA8 →	+1.878	+1.808	<.001	.001	3	3
LARGE_INTESTINE	DIMT1 →	+0.497	+1.808	.001	.001	3	3
LUNG_NSCLC_LUSC	C3orf22 →	+0.037	+3.765	.001	.003	3	2
LUNG_NSCLC_LUSC	KRTAP19-1 →	+0.507	+3.459	.002	<.001	3	2
LUNG_NSCLC_LUSC	OR9A4 →	+0.163	+2.684	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,267 associations by consensus.

FANCE by SMG1 expression — LARGE_INTESTINE

Explore this box plot interactively →