SMDT1

Across TCGA pan-cancer cohorts, SMDT1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SMDT1 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SMDT1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SMDT1 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and OV are the cancer types where SMDT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.865	.032	60	view →
PDAC	DFS	Median	III,IV	0.877	0.280	.004	9	view →
OV	DFS	Median	All	1.000	0.849	.022	8	view →
CCRCC	OS	Median	II,III,IV	1.000	0.373	.006	7	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	6	view →
GBM	OS	Median	All	0.263	0.549	.026	2	view →
HNSC	DFS	Median	IV	1.000	0.905	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SMDT1–COAD (DFS)

Open the COAD breakdown →