SMCR8

Across TCGA pan-cancer cohorts, SMCR8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMCR8 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SMCR8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SMCR8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where SMCR8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.449	.010	20	view →
LUAD	DFS	Median	III,IV	0.661	0.401	.014	13	view →
CCRCC	DFS	Tertile	IV	0.908	0.147	.024	6	view →
PDAC	DFS	Quartile	All	0.703	0.850	.043	4	view →
LSCC	OS	Median	III,IV	0.986	0.638	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMCR8–UCEC (OS)

Open the UCEC breakdown →