SMCR8

Across TCGA patient cohorts, SMCR8 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCR8-associated genes across cancer lineages are Notch1, VHL, and ATM. Each is linked with SMCR8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCR8-to-partner and partner-to-SMCR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SMCR8-low versus SMCR8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCR8→partner) and Y-score (partner→SMCR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.143	+2.331	.002	.003	3	2
UCEC	VHL →	-0.997	-2.087	<.001	.004	3	2
UCEC	ATM →	-0.528	-1.938	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.482	+1.584	.009	.034	3	2
UCEC	53BP1 →	+0.300	+2.222	.007	.009	3	2
UCEC	EGFR_pY1068 →	-0.242	-2.807	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Notch1 by SMCR8 expression — UCEC

Explore this box plot interactively →