SMCR8

Across TCGA cell cohorts, SMCR8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,522 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SMCR8-associated GO terms across cancer lineages are Endosomal transport, Regulation of autophagosome maturation, and Negative regulation of brown fat cell differentiation. Each is linked with SMCR8 in more than 16 cancer types. Because this analysis shows association rather than direction, both SMCR8-to-partner and partner-to-SMCR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by SMCR8-low versus SMCR8-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCR8→partner) and Y-score (partner→SMCR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Endosomal transport →	+0.083	+1.216	<.001	.005	3	17
LUNG_NSCLC_LUSC	Regulation of autophagosome maturation →	+0.108	+1.123	<.001	<.001	3	17
OVARY	Negative regulation of brown fat cell differentiation →	+0.202	+0.938	<.001	<.001	3	17
STOMACH	Negative regulation of autophagy →	+0.125	+1.035	<.001	<.001	3	16
OESOPHAGUS	Macroautophagy →	+0.085	+0.984	<.001	.001	3	16
STOMACH	Cytosolic transport →	+0.076	+0.902	.004	.008	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,522 associations by consensus.

Endosomal transport by SMCR8 expression — OESOPHAGUS

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