SMCR8

Across TCGA cell cohorts, SMCR8 mutation is significantly associated with the RNA expression of many other genes, with 142 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMCR8-associated genes across cancer lineages are C20orf141, RBMY1E, and C7orf77. Each is linked with SMCR8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCR8-to-partner and partner-to-SMCR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf141 grouped by SMCR8-low versus SMCR8-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCR8→partner) and Y-score (partner→SMCR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C20orf141 →	+0.106	+4.807	<.001	.006	3	1
SOFT_TISSUE	RBMY1E →	+1.205	+4.930	<.001	.008	3	1
SOFT_TISSUE	C7orf77 →	+0.142	+4.930	<.001	.008	3	1
LARGE_INTESTINE	ASPN →	+0.036	+2.208	<.001	.008	3	1
LARGE_INTESTINE	CCNC →	+0.484	+2.628	.009	.002	3	1
LARGE_INTESTINE	DPF1 →	+0.754	+2.628	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 142 associations by consensus.

C20orf141 by SMCR8 expression — BLOOD_Myeloma

Explore this box plot interactively →