SMCO4P1

Across TCGA pan-cancer cohorts, SMCO4P1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated SMCO4P1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher SMCO4P1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMCO4P1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and LAML show a favorable association.

KICH, BLCA, and KIRP are the cancer types where SMCO4P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.070	0.882	<.001	81	view →
BLCA	OS	Tertile	All	0.222	0.696	<.001	63	view →
KIRP	DFS	Tertile	III,IV	1.000	0.300	.008	48	view →
MESO	OS	Tertile	II,III,IV	0.227	0.565	.012	27	view →
LAML	DFS	Tertile	All	0.766	0.337	.044	24	view →
LUAD	DFS	Tertile	IV	0.223	0.710	.043	18	view →
THCA	DFS	Tertile	III,IV	0.438	0.795	.006	18	view →
ACC	OS	Tertile	All	0.557	0.892	.003	18	view →
UCEC	OS	Tertile	All	0.899	0.930	.024	12	view →
PAAD	OS	Tertile	II,III,IV	0.286	0.560	.028	9	view →
LIHC	OS	Tertile	All	0.501	0.793	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SMCO4P1–KICH (OS)

Open the KICH breakdown →