SMCO4

Across TCGA pan-cancer cohorts, SMCO4 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SMCO4 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SMCO4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SMCO4 expression acts as an unfavorable survival marker.

KIRC and UCEC are the cancer types where SMCO4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.133	0.805	<.001	42	view →
UCEC	OS	Median	III,IV	0.061	0.588	.018	18	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SMCO4–KIRC (OS)

Open the KIRC breakdown →