SMCO4

Across TCGA patient cohorts, SMCO4 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCO4-associated genes across cancer lineages are NMNAT1P4, IGHVII-44-2, and OR4D1. Each is linked with SMCO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCO4-to-partner and partner-to-SMCO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMNAT1P4 grouped by SMCO4-low versus SMCO4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCO4→partner) and Y-score (partner→SMCO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NMNAT1P4 →	+0.068	+7.741	<.001	.009	3	1
COAD	IGHVII-44-2 →	+0.214	+7.741	<.001	.009	3	1
UCEC	OR4D1 →	+0.254	+4.578	<.001	.004	3	1
UCEC	IGFL1P2 →	+0.490	+4.661	<.001	.004	3	1
UCEC	RNU6-1082P →	+0.522	+4.551	<.001	.009	3	1
UCEC	DNMT3AP1 →	+0.125	+4.499	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

NMNAT1P4 by SMCO4 expression — COAD

Explore this box plot interactively →