SMCO4

Across TCGA cell cohorts, SMCO4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,604 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMCO4-associated GO terms across cancer lineages are Aerobic respiration, Cholesterol biosynthetic process via desmosterol, and Zymosterol metabolic process. Each is linked with SMCO4 in more than 7 cancer types. Because this analysis shows association rather than direction, both SMCO4-to-partner and partner-to-SMCO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aerobic respiration grouped by SMCO4-low versus SMCO4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCO4→partner) and Y-score (partner→SMCO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Aerobic respiration →	+0.075	+1.319	.006	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Cholesterol biosynthetic process via desmosterol →	+0.136	+1.687	.004	<.001	3	8
OVARY	Zymosterol metabolic process →	+0.161	+1.530	<.001	<.001	3	8
OVARY	Zymosterol biosynthetic process →	+0.161	+1.530	<.001	<.001	3	8
SOFT_TISSUE	ERBB3 signaling pathway →	+0.160	+1.256	<.001	<.001	3	8
SOFT_TISSUE	ERBB2-ERBB3 signaling pathway →	+0.160	+1.256	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,604 associations by consensus.

Aerobic respiration by SMCO4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →