SMCO3

Across TCGA patient cohorts, SMCO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,154 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SMCO3-associated GO terms across cancer lineages are Cellular response to unfolded protein, Response to topologically incorrect protein, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with SMCO3 in more than 22 cancer types. Because this analysis shows association rather than direction, both SMCO3-to-partner and partner-to-SMCO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to unfolded protein grouped by SMCO3-low versus SMCO3-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCO3→partner) and Y-score (partner→SMCO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Cellular response to unfolded protein →	+0.069	+0.183	.001	<.001	3	23
SCLC	Response to topologically incorrect protein →	+0.082	+0.511	<.001	<.001	3	23
ESCA	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.053	+0.184	<.001	<.001	3	22
STAD	Negative regulation of growth →	+0.036	+0.108	<.001	<.001	3	21
STAD	Vacuole organization →	+0.043	+0.096	<.001	<.001	3	21
UCS	Regulation of non-canonical Wnt signaling pathway →	+0.072	+0.978	<.001	.003	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,154 associations by consensus.

Cellular response to unfolded protein by SMCO3 expression — ESCA

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