SMCO3

Across TCGA patient cohorts, SMCO3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCO3-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Heregulin. Each is linked with SMCO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCO3-to-partner and partner-to-SMCO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SMCO3-low versus SMCO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCO3→partner) and Y-score (partner→SMCO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.284	-2.584	.015	.011	3	1
UCEC	ERK2 →	+0.301	+3.169	<.001	.018	3	1
UCEC	Heregulin →	-0.145	-2.459	.011	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.210	-2.999	.007	.035	3	1
UCEC	JNK2 →	+0.226	+2.834	.014	.034	3	1
UCEC	Rab11 →	-0.149	-3.700	.027	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by SMCO3 expression — UCEC

Explore this box plot interactively →