Across TCGA patient cohorts, SMCO1 mutation is significantly associated with the RNA expression of many other genes, with 535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCO1-associated genes across cancer lineages are OR5AK3P, RNU6-207P, and UBE2V1P15. Each is linked with SMCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCO1-to-partner and partner-to-SMCO1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCO1→partner) and Y-score (partner→SMCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR5AK3P →	+0.026	+4.859	.001	.004	3	2
SKCM	RNU6-207P →	+0.178	+4.199	<.001	.009	3	2
SKCM	UBE2V1P15 →	+0.117	+3.979	<.001	.003	3	2
UCEC	TAF9 →	+0.708	+3.700	<.001	.001	3	1
UCEC	FCGBP →	-1.345	-3.689	.001	.001	3	1
UCEC	UHRF1 →	+0.937	+2.595	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 535 associations by consensus.

Exploration

SMCO1 survival (RNA) · tumor vs normal (RNA) · all SMCO1 data types