Across TCGA patient cohorts, SMCO1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCO1-associated genes across cancer lineages are EGFR, Myosin-IIa_pS1943, and Notch1. Each is linked with SMCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMCO1-to-partner and partner-to-SMCO1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCO1→partner) and Y-score (partner→SMCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.208	-2.321	.009	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.271	+2.335	.008	.020	3	1
UCEC	Notch1 →	+0.237	+3.009	<.001	.019	3	1
UCEC	p62 Lck ligand →	+0.431	+2.321	.008	.035	3	1
UCEC	Rab25 →	-0.467	-2.321	.005	.035	3	1
UCEC	Src_pY416 →	-0.256	-2.308	.034	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

SMCO1 survival (RNA) · tumor vs normal (RNA) · all SMCO1 data types