SMCHD1

Across TCGA pan-cancer cohorts, SMCHD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SMCHD1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SMCHD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMCHD1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where SMCHD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.842	0.956	.008	16	view →
HNSC	OS	Quartile	All	0.804	0.955	.008	15	view →
CCRCC	OS	Quartile	III,IV	0.579	0.995	.012	13	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	6	view →
LSCC	DFS	Median	II,III,IV	1.000	0.419	.008	5	view →
LUAD	DFS	Tertile	All	0.943	0.863	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SMCHD1–UCEC (DFS)

Open the UCEC breakdown →