SMCHD1

Across TCGA patient cohorts, SMCHD1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,122 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SMCHD1-associated proteins across cancer lineages are TYMS, EHMT2, and GABPB1. Each is linked with SMCHD1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMCHD1-to-partner and partner-to-SMCHD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMCHD1 versus TYMS in COAD, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCHD1→partner) and Y-score (partner→SMCHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TYMS →	+0.835	+1.061	.003	.002	3	6
LSCC	EHMT2 →	+0.243	+0.396	.001	.003	3	6
GBM	GABPB1 →	+0.475	+0.522	<.001	<.001	3	6
LSCC	SMC5 →	+0.275	+0.529	.001	.001	3	6
UCEC	NSMCE3 →	+0.342	+0.453	<.001	<.001	3	6
GBM	WIZ →	+0.305	+0.379	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,122 associations by consensus.

SMCHD1 vs TYMS — COAD

Explore this scatter interactively →