SMCHD1

Across TCGA patient cohorts, SMCHD1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,783 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SMCHD1-associated genes across cancer lineages are METTL4, NDC80, and CEP76. Each is linked with SMCHD1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SMCHD1-to-partner and partner-to-SMCHD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMCHD1 versus METTL4 in OV, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCHD1→partner) and Y-score (partner→SMCHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	METTL4 →	+0.647	+0.280	<.001	<.001	3	10
HNSC	NDC80 →	+1.320	+0.355	<.001	<.001	3	10
LSCC	CEP76 →	+0.650	+0.277	<.001	<.001	3	9
GBM	FBXO5 →	+0.804	+0.255	<.001	<.001	3	9
GBM	KIF14 →	+1.126	+0.290	<.001	<.001	3	9
HNSC	TMPO →	+0.956	+0.319	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,783 associations by consensus.

SMCHD1 vs METTL4 — OV

Explore this scatter interactively →