SMCHD1

Across TCGA patient cohorts, SMCHD1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMCHD1-associated genes across cancer lineages are Notch1, PCNA, and 4E-BP1. Each is linked with SMCHD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMCHD1-to-partner and partner-to-SMCHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SMCHD1-low versus SMCHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCHD1→partner) and Y-score (partner→SMCHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.133	+1.331	<.001	.017	3	4
UCEC	PCNA →	+0.233	+1.722	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.292	+2.351	<.001	<.001	3	4
COAD	ASNS →	+0.833	+3.467	<.001	.002	3	4
COAD	Di-Ras3 →	-0.217	-3.000	.013	.034	3	3
COAD	p62 Lck ligand →	+0.431	+3.169	.013	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Notch1 by SMCHD1 expression — UCEC

Explore this box plot interactively →