SMCHD1

Across TCGA cell cohorts, SMCHD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,919 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SMCHD1-associated GO terms across cancer lineages are Regulation of centrosome cycle, Double-strand break repair, and Double-strand break repair via homologous recombination. Each is linked with SMCHD1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SMCHD1-to-partner and partner-to-SMCHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centrosome cycle grouped by SMCHD1-low versus SMCHD1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMCHD1→partner) and Y-score (partner→SMCHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of centrosome cycle →	+0.111	+1.023	.001	<.001	3	17
BONE	Double-strand break repair →	+0.069	+0.804	.004	.001	2	17
BONE	Double-strand break repair via homologous recombination →	+0.086	+0.765	.001	.002	3	16
BONE	Recombinational repair →	+0.085	+0.816	.001	.001	3	16
STOMACH	Positive regulation of DNA repair →	+0.060	+1.039	.001	<.001	3	16
BREAST	Regulation of mitochondrial transcription →	+0.117	+1.079	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,919 associations by consensus.

Regulation of centrosome cycle by SMCHD1 expression — BONE

Explore this box plot interactively →