SMC6

Across TCGA pan-cancer cohorts, SMC6 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMC6 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SMC6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMC6 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, PRAD, and UCEC are the cancer types where SMC6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	0.053	0.729	<.001	18	view →
PRAD	OS	Median	All	0.157	0.883	<.001	12	view →
UCEC	DFS	Median	All	0.960	0.826	.015	12	view →
KIRP	OS	Median	All	0.739	0.903	.045	6	view →
STAD	DFS	Median	All	0.198	0.587	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMC6–CESC (DFS)

Open the CESC breakdown →