SMC6

Across TCGA patient cohorts, SMC6 RNA expression is significantly associated with the RNA expression of many other genes, with 20,686 significant associations in total. ACC shows the largest number of these associations.

The most reproducible SMC6-associated genes across cancer lineages are CWC22, NIPBL, and NEMF. Each is linked with SMC6 in more than 33 cancer types. Because this analysis shows association rather than direction, both SMC6-to-partner and partner-to-SMC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMC6 versus CWC22 in UVM, with a Pearson correlation of 0.83.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC6→partner) and Y-score (partner→SMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	CWC22 →	+1.496	+1.654	<.001	<.001	3	34
UVM	NIPBL →	+1.293	+1.595	<.001	<.001	3	34
UVM	NEMF →	+1.414	+1.597	<.001	<.001	3	34
CHOL	RNF169 →	+1.491	+0.799	<.001	<.001	3	34
UVM	USP47 →	+1.199	+1.660	<.001	<.001	3	34
UVM	UBXN2A →	+1.253	+1.575	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,686 associations by consensus.

SMC6 vs CWC22 — UVM

Explore this scatter interactively →