SMC6

Across TCGA patient cohorts, SMC6 protein abundance is significantly associated with the RNA expression of many other genes, with 16,313 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMC6-associated genes across cancer lineages are CCNB1IP1, E2F1, and METTL4. Each is linked with SMC6 in more than 6 cancer types. Because this analysis shows association rather than direction, both SMC6-to-partner and partner-to-SMC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMC6 versus CCNB1IP1 in HNSC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC6→partner) and Y-score (partner→SMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCNB1IP1 →	+0.871	+0.332	<.001	<.001	3	7
BRCA	E2F1 →	+1.053	+0.216	<.001	.001	3	6
HNSC	METTL4 →	+0.659	+0.224	.001	.002	3	6
GBM	CENPA →	+1.000	+0.354	<.001	<.001	3	6
BRCA	PARP2 →	+0.445	+0.256	.002	<.001	3	6
HNSC	POLA2 →	+0.655	+0.286	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,313 associations by consensus.

SMC6 vs CCNB1IP1 — HNSC

Explore this scatter interactively →