SMC6

Across TCGA patient cohorts, SMC6 mutation is significantly associated with the RNA expression of many other genes, with 2,537 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMC6-associated genes across cancer lineages are FBXO7, KCTD9, and KLHL18. Each is linked with SMC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMC6-to-partner and partner-to-SMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO7 grouped by SMC6-low versus SMC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC6→partner) and Y-score (partner→SMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO7 →	+0.362	+2.565	<.001	<.001	3	3
UCEC	KCTD9 →	+0.562	+1.642	<.001	<.001	3	3
UCEC	KLHL18 →	+0.413	+1.981	<.001	<.001	3	3
UCEC	MED18 →	+0.377	+1.653	<.001	<.001	3	3
UCEC	LDHA →	+0.522	+1.830	<.001	<.001	3	3
UCEC	RMDN3 →	+0.355	+1.840	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,537 associations by consensus.

FBXO7 by SMC6 expression — UCEC

Explore this box plot interactively →