SMC6

Across TCGA cell cohorts, SMC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,776 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SMC6-associated GO terms across cancer lineages are Centrosome duplication, Regulation of centrosome duplication, and Regulation of chromosome organization. Each is linked with SMC6 in more than 17 cancer types. Because this analysis shows association rather than direction, both SMC6-to-partner and partner-to-SMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome duplication grouped by SMC6-low versus SMC6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC6→partner) and Y-score (partner→SMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Centrosome duplication →	+0.123	+0.789	<.001	.001	3	17
OESOPHAGUS	Regulation of centrosome duplication →	+0.089	+0.817	.007	.004	2	18
SOFT_TISSUE	Regulation of chromosome organization →	+0.094	+0.972	<.001	<.001	3	17
KIDNEY	Regulation of cell cycle checkpoint →	+0.101	+0.787	<.001	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle G2/M phase transition →	+0.100	+1.300	<.001	<.001	3	16
OESOPHAGUS	Microtubule organizing center organization →	+0.085	+0.712	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,776 associations by consensus.

Centrosome duplication by SMC6 expression — OESOPHAGUS

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