SMC6

Across TCGA cell cohorts, SMC6 mutation is significantly associated with the RNA expression of many other genes, with 241 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMC6-associated genes across cancer lineages are GPR119, OR2T1, and PDYN. Each is linked with SMC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMC6-to-partner and partner-to-SMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by SMC6-low versus SMC6-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC6→partner) and Y-score (partner→SMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR119 →	+0.040	+4.906	<.001	.006	3	1
OESOPHAGUS	OR2T1 →	+0.013	+4.906	<.001	.006	3	1
SOFT_TISSUE	PDYN →	+0.048	+3.807	.002	.006	3	1
SOFT_TISSUE	SCGB1D2 →	+0.221	+3.999	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.052	+4.392	<.001	.004	3	1
SOFT_TISSUE	IFNL1 →	+0.177	+3.865	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 241 associations by consensus.

GPR119 by SMC6 expression — OESOPHAGUS

Explore this box plot interactively →