Across TCGA pan-cancer cohorts, SMC5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMC5 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMC5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SMC5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and COAD are the cancer types where SMC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.571	0.879	<.001	52	view →
CCRCC	OS	Median	All	0.924	0.758	.003	20	view →
COAD	DFS	Median	II,III,IV	0.890	1.000	.033	12	view →
PDAC	DFS	Tertile	IV	0.752	0.199	.024	3	view →
LSCC	DFS	Quartile	II,III,IV	0.852	0.537	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SMC5 tumor-vs-normal RNA expression · all SMC5 data types