Across TCGA patient cohorts, SMC5 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,187 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMC5-associated proteins across cancer lineages are FUBP3, PRPF4, and WDR5. Each is linked with SMC5 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMC5-to-partner and partner-to-SMC5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC5→partner) and Y-score (partner→SMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FUBP3 →	+0.222	+0.449	<.001	<.001	3	6
HNSC	PRPF4 →	+0.229	+0.651	<.001	<.001	3	6
GBM	WDR5 →	+0.271	+0.420	<.001	<.001	3	5
GBM	PHF2 →	+0.220	+0.415	.004	<.001	3	5
LSCC	EHMT1 →	+0.329	+0.563	<.001	<.001	3	5
LSCC	GATAD2B →	+0.267	+0.566	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,187 associations by consensus.

Exploration

SMC5 survival (RNA) · tumor vs normal (RNA) · all SMC5 data types