Across TCGA patient cohorts, SMC5 protein abundance is significantly associated with the RNA expression of many other genes, with 18,153 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMC5-associated genes across cancer lineages are RAD51, GINS1, and TAF5. Each is linked with SMC5 in more than 6 cancer types. Because this analysis shows association rather than direction, both SMC5-to-partner and partner-to-SMC5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC5→partner) and Y-score (partner→SMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RAD51 →	+0.638	+0.303	<.001	<.001	3	7
UCEC	GINS1 →	+0.885	+0.258	<.001	.001	3	7
HNSC	TAF5 →	+0.527	+0.196	.002	.001	3	7
LSCC	SMC6 →	+0.557	+0.313	<.001	<.001	3	7
UCEC	TROAP →	+1.086	+0.280	<.001	<.001	3	6
HNSC	TICRR →	+0.953	+0.258	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,153 associations by consensus.

Exploration

SMC5 survival (RNA) · tumor vs normal (RNA) · all SMC5 data types