Across TCGA patient cohorts, SMC5 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMC5-associated genes across cancer lineages are PDCD4, Di-Ras3, and p38-MAPK_pT180_Y182. Each is linked with SMC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMC5-to-partner and partner-to-SMC5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC5→partner) and Y-score (partner→SMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.678	-2.584	<.001	<.001	3	3
UCEC	Di-Ras3 →	-0.114	-2.446	.021	.018	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.589	-3.045	<.001	<.001	3	2
BLCA	Cyclin-E2 →	+0.243	+3.038	.007	.017	3	2
UCEC	14-3-3_beta →	-0.070	-1.847	.037	.049	3	2
UCEC	mTOR_pS2448 →	-0.173	-2.489	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

SMC5 survival (RNA) · tumor vs normal (RNA) · all SMC5 data types