Across TCGA cell cohorts, SMC5 mutation is significantly associated with the RNA expression of many other genes, with 277 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMC5-associated genes across cancer lineages are FFAR3, LRIT1, and KRTAP5-10. Each is linked with SMC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMC5-to-partner and partner-to-SMC5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC5→partner) and Y-score (partner→SMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FFAR3 →	+0.022	+3.906	.002	.009	3	1
LUNG_NSCLC_LUAD	LRIT1 →	+0.029	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	KRTAP5-10 →	+0.030	+3.678	.006	.009	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
LARGE_INTESTINE	EIF3L →	+0.501	+3.237	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 277 associations by consensus.

Exploration

SMC5 survival (RNA) · tumor vs normal (RNA) · all SMC5 data types