Across TCGA cell cohorts, SMC5 mutation is significantly associated with the mutation status of many other genes, with 5,722 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMC5-associated genes across cancer lineages are GNAS, COL16A1, and TECPR2. Each is linked with SMC5 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMC5-to-partner and partner-to-SMC5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC5→partner) and Y-score (partner→SMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GNAS →	+3.047	+4.510	.001	.001	1	6
UPPER_AERODIGESTIVE_TRACT	COL16A1 →	+4.392	+4.954	.008	.008	1	5
CNS	TECPR2 →	+5.277	+4.459	.005	.005	1	5
BLOOD_Lymphoma	PTPN23 →	+3.337	+3.201	.001	.001	1	5
PANCREAS	EML5 →	+5.115	+5.115	.005	.005	1	5
UPPER_AERODIGESTIVE_TRACT	TNIK →	+4.392	+4.954	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,722 associations by consensus.

Exploration

SMC5 survival (RNA) · tumor vs normal (RNA) · all SMC5 data types