SMC5-AS1

Across TCGA pan-cancer cohorts, SMC5-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SMC5-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SMC5-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMC5-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUAD show a favorable association.

ACC, LGG, and UCS are the cancer types where SMC5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.162	0.642	<.001	65	view →
LGG	OS	Median	All	0.749	0.877	<.001	45	view →
UCS	DFS	Median	II,III,IV	0.583	0.279	.010	22	view →
LUAD	OS	Tertile	All	0.855	0.732	.018	18	view →
KIRP	OS	Quartile	II,III,IV	1.000	0.734	.012	17	view →
SARC	DFS	Median	All	0.536	0.680	<.001	17	view →
LAML	DFS	Median	All	0.539	0.273	.015	16	view →
STAD	DFS	Quartile	IV	0.222	0.736	.015	12	view →
KIRC	DFS	Quartile	All	0.709	0.510	.004	8	view →
SKCM	DFS	Quartile	All	0.682	0.545	.014	7	view →
THCA	OS	Median	III,IV	0.990	0.954	.032	6	view →
PCPG	OS	Quartile	All	0.884	1.000	.039	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

SMC5-AS1–ACC (DFS)

Open the ACC breakdown →